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1. Pick me. Choose me. Love me.
Dramatic love declarations are Grey's Anatomy's specialty, but this Meredith confession trumped them all. When Derek had doubts about signing his divorce papers with Addison, Meredith pleaded with him and asked him to choose her instead, which led to one of the most iconic TV speeches of all time:

*ahem*

"Your choice? It’s simple. Her, or me," Meredith said. "And I’m sure she’s really great. But Derek, I love you. In a… really, really big… pretend to like your taste in music, let you eat the last piece of cheesecake, hold a radio over my head outside your window, unfortunate way that makes me hate you, love you. So pick me. Choose me. Love me."